England and Wales are set to face off in an exciting clash at Twickenham in the Six Nations. England started their campaign with a win over Italy, while Wales lost narrowly to Scotland. England has had a strong record against Wales at Twickenham since 2012, winning seven consecutive matches. Wales can take heart from their victory over England in the 2015 World Cup, but they face a tough challenge to turn things around. Wales will be boosted by the return of George North, who has been part of a winning Wales team at Twickenham and will reach 50 Six Nations games. The inclusion of ex-Cardiff native Immanuel Feyi-Waboso in the England team has caused controversy, with Wales coach Warren Gatland expressing his disappointment. England returns to Twickenham after being booed during a Rugby World Cup warm-up match against Fiji, and changes have been made to improve the matchday experience. Ioan Lloyd, a young player for Wales, will make his first start in the number 10 shirt, and his performance will be crucial for Wales' chances of upsetting England.