The Walter White nickname "Heisenberg" was well-known in Breaking Bad and had a significant meaning. Bryan Cranston played the character for five seasons and one of the most compelling storylines focused on Walt's transformation into the ruthless drug kingpin named after Werner Heisenberg. Walter White chose the alias Heisenberg for a reason. The name allowed him to gain notoriety while hiding his true identity. Additionally, the name and appearance helped him separate himself from his actions and suppress guilt. The connection to Heisenberg's uncertainty principle adds another layer to the alias's significance.